LORIS (Longitudinal Online Research and Imaging System) is a web-based data and project management software for neuroimaging research studies. It is a very convenient tool for researchers conducting neuroimaging research studies, as they are often statistically underpowered because of the difficulty to get data from enough subjects. The obvious solution to increase the datasets’ size is to collect data from multiple sites, but using data with multiple sources needs a very high level of care to make the data collected compatible. Neuroscience is very interdisciplinary and not all researchers involved in the process should have to collect their own data to do what they do best. Thus, LORIS should help to reduce useless redundancy of studies, or at least put them together to make better studies. The REST API is an easy way to securely access, retrieve and manipulate the sensitive data about the subjects stored in LORIS. The information stored in Loris is very personal to the subjects, so the security of these actions on Loris’ database is of foremost importance for ensuring the subjects confidentiality.