ABioTrans Plus is a web server for transcriptome data analysis and visualization. It supports the analysis of microarray and RNASeq data and performs ten different bio-statistical analyses that cover the common analytics for gene expression data. Furthermore, it gives the users access to several bioinformatics tools to perform 12 different bioinformatics analyses on gene/protein datasets. This project aims to develop ABioTrans Plus v3.0 which will support a wider range of high throughput omics data, namely MS-based proteomics and metabolomics data. Furthermore, developing a detailed report with the performed analysis with figures and data ready to be included in the publications. Machine learning is a method of data analysis that automates analytical model building. It is a branch of artificial intelligence based on the idea that systems can learn from data, identify patterns and make decisions with minimal human intervention. Machine learning has been used broadly in biological studies for prediction and discovery.