Integrating CAD and CAM tools for automating a synthetic biology workflow
- Mentors
- Chris Myers, Michael Zhang, Ernst Oberortner
- Organization
- National Resource for Network Biology (NRNB)
Integrated Build Software Optimisation Tools (BOOST) with SBOLDesigner. SBOLDesigner is a CAD tool for creating and manipulating the sequences of genetic constructs using the Synthetic Biology Open Language (SBOL) 2.0 data model and BOOST is a repertoire of CAD/CAM tools for minimizing the cost and time for synthesizing DNA sequences with the maximal success rate of synthesis.
Integration of them enabled automated synthetic biology design-build workflows by providing different functionalities like the DNA Sequence verification against constraints, modification of complex region according to the genetic code, fragmentation of large sequences depending on max. length of synthesis and desired assembly protocol.